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  • Title: Copper(I)-catalyzed multicomponent reaction providing a new access to fully substituted thiophene derivatives.
    Author: Jiang B, Tu XJ, Wang X, Tu SJ, Li G.
    Journal: Org Lett; 2014 Jul 18; 16(14):3656-9. PubMed ID: 24988049.
    Abstract:
    Readily available triethylammonium 1-(2-oxoindolin-3-ylidene)-2-aroylethanethiolates are efficiently converted into a variety of fully substituted thiophene derivatives by copper(I)-catalyzed denitrogenative reactions with terminal alkynes and N-sulfonyl azides. This new reaction simultaneously installs C-N, C-S, and C-C bonds, allowing direct formation of highly functionalized thiophenes with a wide diversity in substituents in a one-pot manner. A plausible mechanism for the domino process is proposed.
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