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  • Title: Long-term persistence of false positive antibody reactivity in HIV western blot testing of sera from a healthy blood donor.
    Author: Settergren B, Burman LA, Gustafsson A, Juto P, Li QG, Wadell G.
    Journal: Scand J Infect Dis; 1989; 21(2):233-5. PubMed ID: 2499039.
    Abstract:
    HIV-Western blot (WB) testing of sequential sera from a blood donor revealed identical bands in the p24 and p55 positions. Additional testing using indirect immunofluorescence antibody technique, radioimmunoprecipitation assay and an HIV p24 antigen immunoassay were negative. During a 5-year follow-up period the blood donor has remained apparently healthy and no signs of disease have developed. We conclude that sera from this blood donor show a false positive HIV WB reactivity. The nature of this reactivity remains obscure but has practical implications for the routine HIV screening of blood donors.
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