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  • Title: [Acid-base homeostasis: metabolic acidosis and metabolic alkalosis].
    Author: Dussol B.
    Journal: Nephrol Ther; 2014 Jul; 10(4):246-57. PubMed ID: 24993393.
    Abstract:
    Acid-base homeostasis ensured by the kidneys, which maintain the equilibrium between proton generation by cellular metabolism and proton excretion in urine. This requirement is lifesaving because of the protons' ability to bind to anionic proteins in the extracellular space, modifying their structure and functions. The kidneys also regenerate bicarbonates. The kidney is not the sole organ in charge of maintaining blood pH in a very narrow range; lungs are also involved since they allow a large amount of volatile acid generated by cellular respiration to be eliminated.
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