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  • Title: Enhanced enamel benefits from a novel toothpaste and dual phase gel containing calcium silicate and sodium phosphate salts.
    Author: Hornby K, Ricketts SR, Philpotts CJ, Joiner A, Schemehorn B, Willson R.
    Journal: J Dent; 2014 Jun; 42 Suppl 1():S39-45. PubMed ID: 24993854.
    Abstract:
    OBJECTIVE: To investigate the enamel health benefits of a novel toothpaste and a dual phase gel containing calcium silicate, sodium phosphate and fluoride. METHODS: Enamel demineralisation was assessed using two pH cycling protocols with either lactic acid or citric acid as the acid challenge. Remineralisation of lactic acid softened and citric acid softened enamel was assessed using a number of protocols. All demineralisation and remineralisation evaluation was by surface microhardness measurements. RESULTS: The novel calcium silicate/phosphate fluoride toothpaste inhibited enamel demineralisation to a significantly (p<0.05) greater extent than control formulations, including a fluoride control. The novel calcium silicate/phosphate fluoride toothpaste also showed significant (p<0.05) remineralisation of lactic acid and citric acid softened enamel compared to fluoride and non-fluoride controls. The addition of the novel calcium silicate/phosphate fluoride dual phase gel provided enhanced remineralisation of citric acid softened enamel compared to fluoride and non-fluoride controls. CONCLUSIONS: These studies show that formulations containing calcium silicate, sodium phosphate salts and fluoride provide enhanced enamel demineralisation and remineralisation in vitro benefits. CLINICAL SIGNIFICANCE: The novel oral care formulations containing calcium silicate, sodium phosphate salts and fluoride is a new approach to the protection of enamel from acid attacks and the repair of demineralised enamel, leading to increased dental hard tissue benefits.
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