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  • Title: Highly selective and sensitive nucleic acid detection based on polysaccharide-functionalized silver nanoparticles.
    Author: Yan JK, Ma HL, Cai PF, Wu JY.
    Journal: Spectrochim Acta A Mol Biomol Spectrosc; 2015 Jan 05; 134():17-21. PubMed ID: 24995414.
    Abstract:
    Polysaccharide-functionalized silver nanoparticles (Oc-AgNPs) with a mean diameter of 15 nm were utilized as a novel and effective fluorescence-sensing platform for nucleic acid detection. Tests on the oligonucleotide sequences associated with the human immunodeficiency virus as a model system showed that the Oc-AgNPs effectively absorbed and quenched dye-labeled single-stranded DNA through strong hydrogen bonding interactions and slight electrostatic attractive interactions. The proposed system efficiently differentiated between complementary and mismatched nucleic acid sequences with high selectivity and good reproducibility at room temperature.
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