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  • Title: [The effect of a lipid food component on enzymatic activity of rat liver endoplasmic reticulum upon the action of polychlorinated biphenyls].
    Author: Lashneva NV, Khan AV, Sorokovaia GK, Ishkova VIu, Gadzhiyeva ZM.
    Journal: Vopr Pitan; 1989; (2):24-30. PubMed ID: 2499985.
    Abstract:
    The authors have studied the character of changes in the content of cytochrome P450 and b5, in the oxidation rate of amidopyrine, dimethyl-aniline and aniline, in the NADPH- and ascorbate-dependent lipid peroxidation systems, as well as in glucose-6-phosphatase and acetylesterase activities in the liver microsomes of the rats on semisynthetic diets, including 50% (according to calorific value) of butter or sunflower oil, or receiving fat-free diet (0.5% of sunflower oil) in different terms (4 and 70 days) after a single intragastric administration of a mixture of polychlorinated diphenyls, chlorinated biphenyl (500 mg/kg). It is shown that the degree and character of the microsomal enzymes studied, as well as the changes in the liver structure under the action of chlorinated biphenyl depend, to a certain extent, on the quality and quantity of fat in the diet.
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