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  • Title: The effect of triiodothyronine on the association of the rat apolipoprotein A-I, C-III and A-IV genes with the nuclear matrix.
    Author: Apostolopoulos JJ, La Scala MJ, Shen PY, Howlett GJ.
    Journal: Biochem Biophys Res Commun; 1989 Jun 15; 161(2):576-82. PubMed ID: 2500121.
    Abstract:
    The association of apolipoprotein genes with the nuclear matrix of rat liver has been studied. The proportion of the apolipoprotein (apo) A-I, A-IV, C-III and E genes and the albumin gene associated with the matrix in normal rat liver was approximately 11%. In hypothyroid rats, the association of the apo A-I and apo A-IV genes with the matrix was reduced to 1.3% and 2.1% respectively, while in hyperthyroid rats, the association increased to 59% and 39% respectively. In contrast, the association of the apo C-III gene, which is located between the A-I and A-IV genes on chromosome 11, was not significantly affected by thyroid status. The association of the apo E and albumin genes with the matrix was also unaltered by changes in thyroid status. The increased association of the apo A-I and A-IV genes with the nuclear matrix of hyperthyroid animals accompanies the transcriptional activation of these genes by thyroid hormones.
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