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  • Title: Immunohistochemical detection of a substance resembling growth hormone-releasing factor in the brain of the rainbow trout (Salmo gairdneri).
    Author: Luo D, McKeown BA.
    Journal: Experientia; 1989 Jun 15; 45(6):577-80. PubMed ID: 2500360.
    Abstract:
    We studied the distribution of an immunoreactive substance resembling growth hormone-releasing factor (GRF) in the hypothalamus and pituitary gland of the rainbow trout by immunofluorescence methods. The GRF-like immunoreactive perikaryon was observed in colchicine-treated fish. The majority of GRF-containing neurons were located in the nucleus lateral tuberis; others were located in the caudal part of the preoptic nucleus of the hypothalamus. The GRF-like immunoreactive neuronal processes projected into the pars distalis via the pars nervosa of the pituitary gland. The distribution of the GRF-like immunoreactive substance in the hypothalamus and pituitary gland suggests that GRF plays a physiological role in the regulation of growth hormone release from the pituitary gland of rainbow trout, as it does in mammals.
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