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  • Title: Compounds from the aerial parts of Piper bavinum and their anti-cholinesterase activity.
    Author: Dung HV, Cuong TD, Chinh NM, Quyen D, Kim JA, Byeon JS, Woo MH, Choi JS, Min BS.
    Journal: Arch Pharm Res; 2015; 38(5):677-82. PubMed ID: 25005067.
    Abstract:
    A new alkenylphenol, bavinol A (1), together with six known compounds (2-7) were isolated from the aerial parts of Piper bavinum (Piperaceae). The chemical structures of these compounds were determined by spectroscopic analyses including 2D NMR spectroscopy. The anti-Alzheimer effects of compounds 1-7 were evaluated from acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity assays. Bavinol A (1), ampelopsin (3), and violanthin (4) exhibited AChE inhibitory activities with IC50 values of 29.80, 59.47 and 79.80 μM. Compound 1 also showed the most potent BChE inhibitory activity with an IC50 value of 19.25 μM.
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