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  • Title: Emerging roles of heterogeneous nuclear ribonucleoprotein K (hnRNP K) in cancer progression.
    Author: Barboro P, Ferrari N, Balbi C.
    Journal: Cancer Lett; 2014 Oct 01; 352(2):152-9. PubMed ID: 25016060.
    Abstract:
    The heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a nucleic acid-binding protein that serves as a docking platform integrating transduction pathways to nucleic acid -directed processes. Recently, this protein has emerged as an important player in carcinogenesis process. HnRNP K is overexpressed in several human cancers and its aberrant cytoplasmic localization has been associated with a worse prognosis for patients, suggesting that it has a role in cancer progression. Herein, we provide a brief overview of the multifunctional roles of hnRNP K and discuss clinical studies that have demonstrated its involvement in cancer development and progression.
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