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  • Title: [Meiotic segregation of chromosomes 13 and 14 of heterozygous Robertsonian translocation der(13;14) (q10; q10) carriers].
    Author: Pilip LIa, Spinenko LA, Zukin VD, Bil'ko NM.
    Journal: Tsitol Genet; 2014; 48(3):48-53. PubMed ID: 25016829.
    Abstract:
    Meiotic segregation of chromosomes 13 and 14 was assessed by fluorescence in situ hybridization on sperm of five heterozygous carriers of the most frequent Robertsonian translocation der(13;14). Alternate segregation mode was predominant (mean 78.2 +/- 5.7%). The prevalence of balanced sperm varied from 69.4 to 86.5%. Adjacent segregation mode was detected in 18.64 +/- 4.90% of sperm; 3:0 mode was detected in 2.48 +/- 1.20% of sperm. These results are informative for reproductive counseling of Robertsonian translocation der(13;14) carriers, providing information for assessment of probability of receiving normal/balanced embryos in assisted reproduction cycles.
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