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  • Title: Effects of 2-nitratopropyl 3-nitratopropyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate on cerebral circulation and metabolism in cats.
    Author: Izumi Y, Isozumi K, Fukuuchi Y, Gotoh F.
    Journal: Arzneimittelforschung; 1989 Apr; 39(4):438-40. PubMed ID: 2502125.
    Abstract:
    Effects of CD-349 (2-nitratopropyl 3-nitratopropyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate) on cerebral circulation and metabolism were examined measuring cerebral oxygen and carbon dioxide tension (BrPO2, BrPCO2), pH (BrpH) and mean arterial blood pressure (MABP) in cats. CD-349 of 10 micrograms/kg infused into the carotid artery produced a remarkable and long-lasting decrease in systemic blood pressure, whereas BrPO2, BrPCO2 and BrpH did not change significantly. The previous studies have already demonstrated that CD-349 increases cerebral blood flow (CBF). In addition to the improvement of the cerebral circulation, the present study suggests that C-349 may augment cerebral metabolism.
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