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  • Title: Discovery of S-adenosyl-L-homocysteine hydrolase inhibitors based on non-adenosine analogs.
    Author: Nakao A, Suzuki H, Ueno H, Iwasaki H, Setsuta T.
    Journal: Bioorg Med Chem Lett; 2014 Sep 01; 24(17):4336-40. PubMed ID: 25022879.
    Abstract:
    High throughput screening using Automated Ligand Identification System (ALIS) resulted in the discovery of a new series of S-adenosyl-L-homocysteine hydrolase inhibitors based on non-adenosine analogs. The optimization campaign led to very potent and competitive compound 39 with a Ki value of 1.5 nM. Compound 39 could be a promising lead compound for research to reduce elevated homocysteine levels.
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