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  • Title: Enantioselective synthesis of α,α-difluoro-β-lactams using amino alcohol ligands.
    Author: Tarui A, Ikebata T, Sato K, Omote M, Ando A.
    Journal: Org Biomol Chem; 2014 Sep 07; 12(33):6484-9. PubMed ID: 25023965.
    Abstract:
    A practical and highly enantioselective Reformatsky reaction of ethyl bromodifluoroacetate with imines using a cheap and commercially available amino alcohol ligand is described. A variety of α,α-difluoro-β-lactams were obtained in up to 74% yield with high enantioselectivity in excess of 99% ee. The use of ethyl bromodifluoroacetate provides for ease of operation because of the inherent chemical stability of this reagent.
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