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  • Title: First case of IgG4-related sclerosing cholangitis associated with autoimmune hemolytic anemia.
    Author: Masutani H, Okuwaki K, Kida M, Yamauchi H, Imaizumi H, Miyazawa S, Iwai T, Takezawa M, Koizumi W.
    Journal: World J Gastroenterol; 2014 Jul 14; 20(26):8740-4. PubMed ID: 25024635.
    Abstract:
    To our knowledge, patients with immunoglobulin G4-related sclerosing cholangitis (IgG4-SC) associated with autoimmune hemolytic anemia (AIHA) have not been reported previously. Many patients with IgG4-SC have autoimmune pancreatitis (AIP) and respond to steroid treatment. However, isolated cases of IgG4-SC are difficult to diagnose. We describe our experience with a patient who had IgG4-SC without AIP in whom the presence of AIHA led to diagnosis. The patient was a 73-year-old man who was being treated for dementia. Liver dysfunction was diagnosed on blood tests at another hospital. Imaging studies suggested the presence of carcinoma of the hepatic hilus and primary sclerosing cholangitis, but a rapidly progressing anemia developed simultaneously. After the diagnosis of AIHA, steroid treatment was begun, and the biliary stricture improved. IgG4-SC without AIP was thus diagnosed.
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