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  • Title: A functional EGF+61 polymorphism is associated with severity of obstructive sleep apnea.
    Author: Ding Q, Cao C, Chen Z, Tabusi M, Chen L, Deng Z.
    Journal: Sleep Breath; 2015 May; 19(2):495-8. PubMed ID: 25028172.
    Abstract:
    BACKGROUND: Involvement of epidermal growth factor (EGF) is reported in diseases caused by hypoxia. Its functional polymorphism may alter its transcription, affecting EGF expression, contributing to obstructive sleep apnea (OSA). OBJECTIVE: The aim of this study was to investigate associations of EGF+61 polymorphism and risk of OSA. METHODS: Two hundred two participants were enrolled in this case-control study. DNA was extracted from peripheral blood, and EGF 61A/G polymorphism was determined using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. RESULTS: No significant association between EGF 61 A/G polymorphism and risk of OSA was observed in any of the gene models tested (AA vs. GG: OR = 0.97, 95% CI = 0.37-2.55; P = 0.95). However, compared with GG genotype, AG genotype associated with decreased risk of severe OSA (AG vs. GG: OR = 0.32, 95% CI = 0.11-0.94). CONCLUSIONS: Our study showed that AG genotype has a protective effect on OSA patients against severe disease, although EGF 61A/G polymorphisms have no role on the risk of the disease. Additional large studies should further validate our findings.
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