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  • Title: Cost-effective assays for use in monitoring carbamazepine, phenobarbital, and phenytoin in serum.
    Author: Moore FM, Simpson D.
    Journal: Clin Chem; 1989 Aug; 35(8):1782-4. PubMed ID: 2503270.
    Abstract:
    Using Syva "EMIT" reagents and the Cobas Bio centrifugal analyzer, we have developed cost-effective assays for therapeutic drug monitoring of carbamazepine, phenobarbital, and phenytoin. With these optimized methods one can assay up to 2470 samples with a single 100-test EMIT kit with good precision and accuracy. Between-batch CVs, based on results of repeat analysis of routine patients' samples, were 4.6%, 7.0%, and 5.3%, respectively. Results correlated well with those by methods previously used [gas chromatography and fluorescence polarization (Abbott TDx)], but there was a negative bias (-10.9%) of our method for phenobarbital results in patients' samples, as compared with those obtained with the TDx.
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