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  • Title: Clinical and biochemical heterogeneity of depressive disorders.
    Author: Maas JW.
    Journal: Ann Intern Med; 1978 Apr; 88(4):556-63. PubMed ID: 25035.
    Abstract:
    Indirect evidence, mostly pharmacologic, has suggested a role for brain neurotransmitter amines such as norepinephrine in the production of depression or mania. Clinical investigations have supported this concept but also indicate that depression is probably a biochemically heterogeneous group of illnesses. There may be a clinically, biochemically, and pharmacologically definable subtype of depression in which there is a disorder of norepinephrine metabolism or disposition in brain. I review here the experimental data from which this hypothesis is derived.
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