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  • Title: Rapid analysis of sorbitol, galactitol, mannitol and myoinositol mixtures from biological sources.
    Author: Eades DM, Williamson JR, Sherman WR.
    Journal: J Chromatogr; 1989 May 05; 490(1):1-8. PubMed ID: 2503529.
    Abstract:
    The three commonly found hexitols mannitol, sorbitol and galactitol are well separated from each other and from myoinositol by gas chromatography as their butylboronate derivative on Dexsil-400, on a 1:1 mixture of OV-1 and OV-17, or on a DB-17 fused-silica capillary column. The method allows all four substances to be measured by autosampling electron ionization gas chromatography-mass spectrometry (GC-MS) in small tissue samples at organ concentrations as small as 5 mumol/kg wet mass in less than 4 min. Comparisons were made to determine the relative sensitivity of GC-MS and other detection methods. The order of sensitivity was electron ionization GC-MS greater than chemical ionization GC-MS greater than flame photometric detection using a boron-selective filter greater than hydrogen flame ionization detection.
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