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  • Title: Impairment of memory in a delayed non-matching to place task following mamillary body lesions in mice.
    Author: Beracochea DJ, Alaoui-Bouarraqui F, Jaffard R.
    Journal: Behav Brain Res; 1989 Aug 01; 34(1-2):147-54. PubMed ID: 2504224.
    Abstract:
    This study assessed the effects of a mamillary body (MM) lesion on memory measured in a delayed non-matching to place task performed in an 8-arm radial maze using BALB/c mice as subjects. In this task, the subjects had to recognize (test-phase) a non-visited arm from a previously visited arm (the sample-place) and were required to enter the non-visited arm in order to get reward. In the first experiment, the difficulty of the recognition was increased by interpolating forced visits (1 to 5; i.e. the study-phase) between the sample-place and the test-phase. In the second experiment, the number of interpolated visits which followed the study-phase was kept constant (5) but the sample-place was placed either before and after the interfering visits. Our results showed that MM subjects were dramatically impaired as compared to controls when required to recognize after 5 but not after 1 interpolated visits (first experiment). However, this deficit was observed only when the sample-place preceded but not when it followed the interpolated visits (second experiment). Our data emphasize the importance of the MM in memory and amnesia.
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