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  • Title: A tailor-made chimeric thiamine diphosphate dependent enzyme for the direct asymmetric synthesis of (S)-benzoins.
    Author: Westphal R, Vogel C, Schmitz C, Pleiss J, Müller M, Pohl M, Rother D.
    Journal: Angew Chem Int Ed Engl; 2014 Aug 25; 53(35):9376-9. PubMed ID: 25044968.
    Abstract:
    Thiamine diphosphate dependent enzymes are well known for catalyzing the asymmetric synthesis of chiral α-hydroxy ketones from simple prochiral substrates. The steric and chemical properties of the enzyme active site define the product spectrum. Enzymes catalyzing the carboligation of aromatic aldehydes to (S)-benzoins have not so far been identified. We were able to close this gap by constructing a chimeric enzyme, which catalyzes the synthesis of various (S)-benzoins with excellent enantiomeric excess (>99%) and very good conversion.
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