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  • Title: Chronic L-deprenyl does not alter the restoration of striatal dopamine in MPTP-lesioned mice.
    Author: Wiener HL, Hashim A, Lajtha A, Sershen H.
    Journal: J Neurosci Res; 1989 Jul; 23(3):326-9. PubMed ID: 2504936.
    Abstract:
    The present study examined the effect of chronic L-deprenyl on dopaminergic terminal function after mouse striatal terminals were lesioned with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP; 2 x 30 mg/kg s.c.). In the MPTP-lesioned mice, the level of dopamine was decreased by 59% 1 week after MPTP administration and by 22% at 16 weeks. Chronic administration of L-deprenyl (0.1 mg/kg, once weekly for up to 16 weeks) did not alter striatal dopamine metabolism, although monoamine oxidase B activity was reduced by 50% during this 16-week period, and did not alter the rate of restoration of the level of striatal dopamine.
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