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  • Title: The effect of hydroalcoholic extract and essential oil of Heracleum persicum on lipid profile in cholesterol-fed rabbits.
    Author: Hajhashemi V, Dashti G, Saberi S, Malekjamshidi P.
    Journal: Avicenna J Phytomed; 2014 May; 4(3):144-50. PubMed ID: 25050312.
    Abstract:
    OBJECTIVE: This study was designed to investigate the effect of hydroalcoholic extract and essential oil of Heracleum persicum (Apiaceae) on lipid profile of male hyperlipidemic rabbits. MATERIALS AND METHODS: Thirty rabbits were randomly divided into six groups of five each. One group received normal diet and the other groups fed with a high cholesterol (2% W/W) diet for 7 weeks. Vehicle, hydroalcoholic extract (500 and 1000 mg/kg), essential oil (200  l/kg), and lovastatin (5 mg/kg) were administered orally to animals and their effects on lipid profile were evaluated. RESULTS: Essential oil of H. perscum significantly (p<0.05) lowered serum triglyceride level and increased HDL-cholesterol concentration. Moreover, hydroalcoholic extract (1000 mg/kg), essential oil (200  l/kg), and lovastatin significantly (p<0.01) reduced serum concentration of total cholesterol and LDL-cholesterol. CONCLUSION: These findings suggest that essential oil of the plant fruits may have some benefits in reducing cardiovascular risk factors.
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