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  • Title: Metal-free oxidative olefination of primary amines with benzylic C-H bonds through direct deamination and C-H bond activation.
    Author: Gong L, Xing LJ, Xu T, Zhu XP, Zhou W, Kang N, Wang B.
    Journal: Org Biomol Chem; 2014 Sep 14; 12(34):6557-60. PubMed ID: 25050849.
    Abstract:
    An oxidative olefination reaction between aliphatic primary amines and benzylic sp(3) C-H bonds has been achieved using N-bromosuccinimide as catalyst and tert-butyl hydroperoxide as oxidant. The olefination proceeds under mild metal-free conditions through direct deamination and benzylic C-H bond activation, and provides easy access to biologically active 2-styrylquinolines with (E)-configuration.
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