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  • Title: Low-dose vs high-dose intravenous methylprednisolone therapy for acute renal allograft rejection in patients receiving cyclosporin therapy.
    Author: Lui SF, Sweny P, Scoble JE, Varghese Z, Moorhead JF, Fernando ON.
    Journal: Nephrol Dial Transplant; 1989; 4(5):387-9. PubMed ID: 2505189.
    Abstract:
    Three mg/kg bodyweight per day of intravenous methylprednisolone for 3 consecutive days is as effective as 15 mg/kg bodyweight per day of methylprednisolone in reversing acute renal allograft rejection (80% vs 68%; 95% confidence intervals of the difference are -8% to 32%). This dose was not associated with an increased incidence of further rejection episodes. It may not be necessary to continue with the common practice of administering high-dose intravenous methylprednisolone for acute renal graft rejection.
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