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  • Title: [Synthesis of N-N-di(2-dibromoethyl)hydrazides of natural alpha-aminocarboxylic acids].
    Author: Loseva S, Zakhariev S, Stoev S, Taksirov S, Golovinsky E.
    Journal: Pharmazie; 1989 May; 44(5):316-7. PubMed ID: 2505277.
    Abstract:
    In the course of a systematical studies on halogenoethylhydrazides of natural alpha-aminocarboxylic acids and their derivatives, N,N-di(2-bromoethyl)hydrazides of glycine, valine, lysine, phenylalanine, L- and D,L-alanine, leucine, isoleucine and cystine were synthesized. It was shown that N,N-di(2-bromoethyl)hydrazides of amino acids with deblocked amino groups are comparatively toxic and unstable, while the N alpha-protected compounds are stable, nontoxic even at a dose of 625 mg/kg and with a high antitumour effect: 70-92% suppression of tumour growth at a dose of 75 mg/kg.
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