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  • Title: The effect of Harderian adenectomy on the antibody response in chickens.
    Author: Montgomery RD, Maslin WR.
    Journal: Avian Dis; 1989; 33(3):392-400. PubMed ID: 2505743.
    Abstract:
    Intact chicks and those that had their glands of Harder (GH) removed (GHx) at 1 day of age were studied for their response to optically or intraperitoneally (IP) applied antigens. Following exposure of the chicks to sheep red blood cells (SRBCs), killed Brucella abortus, or bovine serum albumin (BSA), serum and tear samples were collected and assayed for antibodies. Of the two sources of antibodies, the serum generally had higher levels than did the tears. The only exception to this occurred in the intact chicks inoculated by the eye, in which serum and tear levels were equivalent. With SRBCs, no difference could be detected between the two routes of inoculation. However, IP inoculation produced higher levels of antibody in the serum of intact and GHx chicks inoculated with B. abortus or BSA and in the tears of the GHx chicks exposed to B. abortus. Removal of the GH resulted in a consistent decrease in antibody levels in the tears, regardless of the route of exposure. Although this effect was noted with all three antigens, it was more pronounced in the trials using B. abortus and BSA. This finding is discussed in terms of describing the importance of the GH as a source of antibodies to optically applied antigens, and its importance as a route of circulating antibody egress. Furthermore, the feasibility of using the antibody response in tears to a test antigen is discussed as a means of measuring the immune status of a functioning GH.
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