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  • Title: Microwave-assisted cobinamide synthesis.
    Author: O Proinsias K, Karczewski M, Zieleniewska A, Gryko D.
    Journal: J Org Chem; 2014 Aug 15; 79(16):7752-7. PubMed ID: 25058239.
    Abstract:
    We present a new method for the preparation of cobinamide (CN)2Cbi, a vitamin B12 precursor, that should allow its broader utility. Treatment of vitamin B12 with only NaCN and heating in a microwave reactor affords (CN)2Cbi as the sole product. The purification procedure was greatly simplified, allowing for easy isolation of the product in 94% yield. The use of microwave heating proved beneficial also for (CN)2Cbi(c-lactone) synthesis. Treatment of (CN)2Cbi with triethanolamine led to (CN)2Cbi(c-lactam).
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