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  • Title: Inhibition of human placenta aldose reductase by tannic acid.
    Author: Sawada H, Hamatake M, Hara A, Nakagawa M, Nakayama T.
    Journal: Chem Pharm Bull (Tokyo); 1989 Jun; 37(6):1662-4. PubMed ID: 2505942.
    Abstract:
    Tannic acid was found to be a highly potent inhibitor of human placenta aldose reductase. The most potent inhibitory component of the tannic acid was isolated and identified as penta-O-galloyl-beta-D-glucose, which showed an IC50 value of 70 nM. The inhibition by the gallotannin was reversible and of mixed type with respect to DL-glyceraldehyde as the varied substrate.
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