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  • Title: Diet-induced maternal obesity alters ovarian morphology and gene expression in the adult mouse offspring.
    Author: Cheong Y, Sadek KH, Bruce KD, Macklon N, Cagampang FR.
    Journal: Fertil Steril; 2014 Sep; 102(3):899-907. PubMed ID: 25063726.
    Abstract:
    OBJECTIVE: To examine the effects of high-fat (HF) diet-induced maternal obesity on follicular population and gene expression in adult offspring ovaries. DESIGN: Experimental mouse study. SETTING: Laboratory. ANIMAL(S): Mice on HF diet. INTERVENTION(S): Female C57BL/6J mice were fed an HF or standard chow (C) diet 6 weeks before conception, through pregnancy and lactation. Offspring were fed the C or HF diet from weaning, creating the HF/HF, HF/C, C/HF, C/C offspring groups. MAIN OUTCOME MEASURE(S): Follicular counts and gene expression in adult offspring ovaries. RESULT(S): Prenatal exposure to maternal HF nutrition resulted in the reduction of primordial, antral, and Graafian follicle numbers in offspring ovaries (both HF/C and HF/HF). Expression levels of genes involved in apoptosis (FoXO3a), follicular growth and development (Gdf9), and circadian rhythms generation (Clock and Bmal1) were elevated in the ovaries of HF/C and HF/HF offspring, while expression of the circadian clock genes Cry1 and Per1 were lower in HF/HF ovaries. CONCLUSION(S): Maternal obesity during pregnancy has long-term deleterious consequences on follicular growth and development in the adult offspring ovaries, which may impact their reproductive potential.
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