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  • Title: Limiting dilution analysis of T cell unresponsiveness to mycobacteria in advanced disseminated tuberculosis.
    Author: Gilardini Montani MS, Del Gallo F, Lombardi G, Del Porto P, Piccolella E, Arienzo F, Colizzi V.
    Journal: Med Microbiol Immunol; 1989; 178(5):235-44. PubMed ID: 2506411.
    Abstract:
    Peripheral blood mononuclear cells from patients with advanced disseminated tuberculosis (Dis-TB) do not respond to purified protein derivative (PPD) measured as cell proliferation, lymphokine production and interleukin (IL)-2 receptor (Tac antigen) expression. Limiting dilution analysis revealed "multi-hit" curves and low frequencies of PPD-reactive T cells in cultures of Dis-TB, and "single-hit" curves and high frequencies of PPD-reactive T cells in cultures of patients with localized form of pulmonary tuberculosis. Moreover, a strict relationship between Tac antigen expression and ability of exogenous IL-2 to enhance bulk culture cell proliferation was observed in Dis-TB patients.
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