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  • Title: Specific cross-protection between Schistosoma bovis and S. haematobium induced by highly irradiated infections in mice.
    Author: Agnew AM, Murare HM, Doenhoff MJ.
    Journal: Parasite Immunol; 1989 Jul; 11(4):341-9. PubMed ID: 2506508.
    Abstract:
    Significant levels of resistance against Schistosoma haematobium challenge were developed by mice exposed to highly irradiated (20 krad) cercariae of the homologous species (46-53%) or of the closely related species, S. bovis (34-56%) but not of S. mansoni (-6-28%). This ability to cross-protect reflects the phylogenetic relationships between these species; S. mansoni and S. bovis, as well as S. mansoni and S. haematobium, failed to cross-protect. The cross-protection demonstrated between S. bovis and S. haematobium in mice was non-reciprocal.
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