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  • Title: A new Rhodamine B-based 'on-off' chemical sensor with high selectivity and sensitivity toward Fe(3+) and its imaging in living cells.
    Author: Bao X, Shi J, Nie X, Zhou B, Wang X, Zhang L, Liao H, Pang T.
    Journal: Bioorg Med Chem; 2014 Sep 01; 22(17):4826-35. PubMed ID: 25065941.
    Abstract:
    A new fluorescent chemosensor based on a Rhodamine B and pyrrole conjugate (RBPY) has been designed and synthesized. UV-vis absorption and fluorescence spectroscopic studies show that RBPY exhibits a high selectivity and sensitivity toward Fe(3+) among many other metal cations in a MeOH/H2O solution (3:2, v/v, pH 7.10, HEPES buffer, 0.1mM) by forming a 1:1 complex with Fe(3+). Furthermore, results reveal that the formation of the RBPY-Fe(3+) complex is fully reversible in the presence of sulfide anions and could also be used as an efficient sensor for S(2-). Importantly, fluorescence microscopy experiments further demonstrated that RBPY can be utilized as a fluorescent probe for the detection of Fe(3+) in human liver (L-02) cells.
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