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  • Title: Ifosfamide and mesna in the treatment of malignant disease mesna as urothelial protector.
    Author: Falkson CI, Falkson HC, Falkson G.
    Journal: Invest New Drugs; 1989 Jul; 7(2-3):261-7. PubMed ID: 2507474.
    Abstract:
    One hundred and forty-six patients with advanced malignant disease were treated with 6 different dosage schedules of ifosfamide (IFX). Mesna was used as urothelial protector. With mesna, urothelial toxicity was moderate, and single doses of up to 7 g/m2 could be administered without intolerable urotoxicity. Leukopenia was the dose-limiting factor in this study. Unexpected pulmonary edema occurred in 3 patients. Therapeutic results were disappointing. A malignancy identified in this study that warrants further investigation with IFX and mesna, is malignant mesothelioma.
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