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  • Title: Drug-induced inhibition of proteoglycanase activity in the Hulth-Telhag model.
    Author: Ishizue KK, Ehrlich MG, Mankin HJ.
    Journal: J Orthop Res; 1989; 7(6):806-11. PubMed ID: 2507757.
    Abstract:
    Evidence has accumulated that there are increased degradative enzymes in osteoarthritis responsible for joint destruction. These enzymes are metal-dependent, and inhibited by EDTA. EDTA was administered intra-articularly to rabbits in an experimental model of osteoarthritis. There was a 25% reduction in neutral proteoglycanase activity and 75% of the animals had a reduction in the severity of the arthritis as measured on a histologic-histochemical grading system. It is suggested that future chemotherapeutic studies on arthritis might focus on enzyme inhibition.
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