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  • Title: Theobromine enhances absorption of cacao polyphenol in rats.
    Author: Yamamoto T, Takahashi H, Suzuki K, Hirano A, Kamei M, Goto T, Takahashi N, Kawada T.
    Journal: Biosci Biotechnol Biochem; 2014; 78(12):2059-63. PubMed ID: 25079983.
    Abstract:
    Several concentrations of theobromine (TB) and (-)-epicatechin (EC) were coadministered to rats, and plasma EC and its metabolites were determined using ultra-high-performance liquid chromatography-tandem mass spectrometry. It has been demonstrated that TB increases the absorption of EC in a dose-dependent manner. Cocoa powder had a similar effect, and the mechanism involved is not thought to depend on tight junctions.
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