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  • Title: Benign cephalic histiocytosis: report of four cases.
    Author: de Luna ML, Glikin I, Golberg J, Stringa S, Schroh R, Casas J.
    Journal: Pediatr Dermatol; 1989 Sep; 6(3):198-201. PubMed ID: 2508072.
    Abstract:
    We cared for four patients with benign cephalic histiocytosis, a self-healing non-X, nonlipid cutaneous histiocytosis of children. The age of onset of the disease was 5 to 9 months, with papules and erythematous macules involving the head (mainly the cheeks), and posterior spread to the trunk and limbs in three patients. Microscopic examination of skin biopsies revealed a histiocytic infiltrate in the superficial dermis that was S100 protein-negative by immunoperoxidase (PAP method). One patient showed comma-shaped bodies and desmosomelike junctions on electron microscopy. No Birbeck's granules were present. Benign cephalic histiocytosis is a self-limiting condition that requires no treatment.
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