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  • Title: [Monoclonal gammopathies of undetermined significance called "MGUS"].
    Author: Clément F.
    Journal: Schweiz Med Wochenschr; 1989 Jul 11; 119(27-28):970-8. PubMed ID: 2508215.
    Abstract:
    While the discovery of a monoclonal gammopathy in the blood of a patient sometimes leads to the diagnosis of multiple myeloma, immunocytoma or other B-cell lymphoproliferative syndromes, "secondary" monoclonal dysproteinemia is seldom considered. In most cases "monoclonal gammopathy of undetermined significance" (MGUS) is diagnosed. After ten years about 25% of these cases evolve to true multiple myeloma or Waldenström's disease. Other MGUS usually remain asymptomatic, though sometimes a complication such as amyloidosis or cryoglobulinemia may occur as a result of the "perverse" effect of the monoclonal protein. Some cases are described.
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