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  • Title: Novel synthesis of gold nanoclusters templated with L-tyrosine for selective analyzing tyrosinase.
    Author: Yang X, Luo Y, Zhuo Y, Feng Y, Zhu S.
    Journal: Anal Chim Acta; 2014 Aug 20; 840():87-92. PubMed ID: 25086898.
    Abstract:
    L-Tyrosine (Tyr), playing roles as both a reducing reagent and a protecting ligand, has been first employed for synthesizing fluorescent gold nanoclusters (AuNCs@Tyr) via a novel one-pot strategy. The as-prepared AuNCs@Tyr exhibited a fluorescence emission at 470 nm with a quantum yield of approximately 2.5%. Subsequently, the AuNCs@Tyr described here was applied for detections of tyrosinase (TR) activity, which was based on the mechanism of aggregations of AuNCs@Tyr occurring on the active sites of TR since TR was introduced, thus leading to the fluorescence quenching of AuNCs@Tyr. Accordingly, TR was analyzed in a linear range of 0.5-200 u mL(-1) with a detection limit of 0.08 u mL(-1) at a signal-to-noise ratio of 3. Significantly, TR has been considered as a critical marker for melanoma owing to its specifically expressing in melanoma cells. Therefore, this analytical method towards investigating TR activity may broaden avenues for meaningfully clinical applications.
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