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  • Title: [Optimization of ultrasonic extraction conditions of safflower yellow from Carthamus tinctorius by response surface methodology].
    Author: Sun YW, He Y, Zhang RP, Huang JW, Gu MC.
    Journal: Zhong Yao Cai; 2013 Dec; 36(12):2018-22. PubMed ID: 25090689.
    Abstract:
    OBJECTIVE: To investigate the optimization of extraction conditions of safflower yellow from Cartbamus tirwtorius by response surface methodology. METHODS: Experimental factors and levels were selected by one-factor test, and then according to the central composite experimental design principle, response surface'-methodology with three factors and three levels was used to establish a mathematical model to obtain the optimal extraction conditions with hydroxysafflower yellow A being the target and its extraction yield as response value. RESULTS: The optimal extraction conditions of safflower yellow were as follows: extraction temperature was 55 t, ratio of water to raw material was 16:1 and extraction time was 39 mm for three times. CONCLUSION: Under these conditions, the extraction yield of safflower yellow is 1.798%, and the relative error between the predicted value with actual value is 2.758%. The optimized method can provide reference for the efficient extraction of safflower yellow from Carthomos tinctorius
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