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  • Title: [Effects of 2-(2-hydroxyphenoxy) acetyl-L-prolinate sodium on antioxidant defense system of the gastric mucosa of rats under conditions of stress action].
    Author: Hadiliia OP, Tymoshenko MO, Dvorshchenko KO, Ostapchenko LI, Vereshchaka VV.
    Journal: Fiziol Zh (1994); 2014; 60(3):60-6. PubMed ID: 25095673.
    Abstract:
    We investigated the preventive effect of low molecular weight organic compound 2-(2-hydroxyphenoxy) acetyl-L-prolinat sodium on erosive and ulcerative lesions in the gastric mucosa caused by stress. It was established that prophylactic administration of this substance to rats at a dose of 1 mg/kg reduced the lesion area by 56.7%. 2-(2-hydroxyphenoxy) acetyl-L-prolinat sodium efficiently restored the impaired pro-/antioxidative balance in the gastric mucosa of rats under stress: the content of diene conjugates was reduced by 1.24 times, TBA-active products reduced by 1.31 times, Schiff's bases reduced by 1.28 times. This effect was accompanied by increased activities of the superoxide dismutase, catalase and of glutathione system.
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