These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Spot urine protein-to-creatinine ratio compared with 24-hour urinary protein in patients with kidney transplant.
    Author: Wahbeh AM.
    Journal: Exp Clin Transplant; 2014 Aug; 12(4):300-3. PubMed ID: 25095707.
    Abstract:
    OBJECTIVES: This study sought to determine the correlation between protein-to-creatinine ratio and 24-hour urinary protein excretion, to examine agreement between the 2 methods, and to determine the discriminant value for protein-to-creatinine ratio that reliably determines significant threshold levels of proteinuria. MATERIALS AND METHODS: Proteinuria was assessed by 24-hour urine protein excretion and protein-to-creatinine ratio. Correlation and limits of agreement between the 2 methods were evaluated. The discriminant cutoff values for spot urine protein-to-creatinine ratio in predicting 24-hour urine protein excretion were determined using receiver operating characteristic curves. RESULTS: A positive correlation (r=0.7459, P < .0001) was found between spot urine protein-to-creatinine ratio and 24-hour urine protein excretion. A Bland-Altman plot shows that the 2 tests have reasonable limits of agreement at a low level of protein excretion, but the limits become wider as protein excretion increases. The area under the receiver operating characteristic curve for urine protein-to-creatinine ratio at various cutoffs was 0.967 (95% confidence interval: 0.880-0.996; P < .0001). The cutoff level of 0.433 had a sensitivity and specificity of 100% and 90%. CONCLUSIONS: We conclude that the protein-to-creatinine ratio in spot urine specimens in patients undergoing a kidney transplant is a convenient and reliable method of estimating protein excretion in urine.
    [Abstract] [Full Text] [Related] [New Search]