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  • Title: Long term oral administration study of pravastatin sodium to beagles for 104 weeks.
    Author: Tarumi C, Matsunuma N, Miyakoshi N, Yamashita K, Masuda H.
    Journal: J Toxicol Sci; 1989 Aug; 14 Suppl 1():85-101. PubMed ID: 2509726.
    Abstract:
    Pravastatin sodium was successively given for 104 weeks to beagles orally at doses of 5 and 25 mg/kg/day. A decrease in serum cholesterol levels was observed at week 4 and thereafter. No other abnormal findings were obtained in any animals in general conditions, hematological and biochemical examination, various function tests, and pathological examinations. The no-effect dose level in beagles receiving pravastatin sodium orally for 104 weeks is toxicologically estimated to be more than 25 mg/kg/day.
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