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  • Title: [Anesthesia for total hip arthroplasty in a patient with C1 inhibitor deficiency].
    Author: Oyaizu T, Kikuchi A, Minoshima R, Nagata H, Sakurai H, Suzuki T, Katori N, Morisaki H.
    Journal: Masui; 2014 Jul; 63(7):820-2. PubMed ID: 25098147.
    Abstract:
    C1 inhibitor (INH) deficiency is characterized by the presence of angioedema of the extremities, face, airway and the gastrointestinal tract. Airway obstruction is the most common cause of mortality. A 78-year-old woman presented with repeated episodes of angioedema. These episodes were triggered by general anesthesia, dental extraction, venipuncture, vaccination and loxoprofen. The familiy history of similar symptoms was negative. C1 inhibitor concentrate was administered perioperatively for prophylaxis of attacks. Operation was performed under neurolept anesthesia and combined spinal-epidural anesthesia in order to avoid airway manipulation. Postoperative pain was controlled by patient-controlled epidural anesthesia to prevent attacks triggered by pain. The patient had angioedema on both lower extremities perioperatively but did not develop further attacks. Anesthesia was safely performed in a patient with C1 inhibitor deficiency scheduled for total hip arthroplasty.
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