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  • Title: Rescue of bicoid mutant Drosophila embryos by bicoid fusion proteins containing heterologous activating sequences.
    Author: Driever W, Ma J, Nüsslein-Volhard C, Ptashne M.
    Journal: Nature; 1989 Nov 09; 342(6246):149-54. PubMed ID: 2509940.
    Abstract:
    The maternal gene bicoid (bcd) determines pattern in the anterior half of the Drosophila embryo. It is reported here that the injection of bcd mutant embryos with messenger RNAs that encode proteins consisting of heterologous acidic transcriptional activating sequences fused to the DNA-binding portion of the bcd gene product, can completely restore the anterior pattern of the embryo.
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