These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effects of rioprostil on bicarbonate secretion by guinea-pig gastric mucosa in vitro.
    Author: Petersen KU, Winterhager JM.
    Journal: Scand J Gastroenterol Suppl; 1989; 164():26-33; discussion 33-4. PubMed ID: 2510277.
    Abstract:
    Spontaneous and prostaglandin-stimulated HCO3 secretions are studied in guinea-pig isolated gastric mucosa by means of pH-stat techniques. Antral mucosa exhibits a spontaneous HCO3- secretion of about 0.5 mumol/cm2h that is almost abolished by serosal addition of indomethacin (10(-5) mol/l). Fundic HCO3- secretion of the same magnitude is revealed upon suppression of acid secretion by serosal omeprazole (10(-5) mol/l). It is stimulated by serosal or mucosal addition of either PGE1, the synthetic primary alcohol analogue of PGE1, rioprostil, or dimethyl-PGE2. Effective concentrations range from 10(-4) to 10(-6) mol/l. Short-circuit current remains unchanged, arguing against involvement of electrogenic mechanisms of HCO3- secretion. Tissue conductance increases in the presence of all compounds tested, but only during luminal exposure to rioprostil does this increase go beyond that observed in time controls. Thus, enhanced HCO3- secretion seems to be due to cellular mechanisms rather than to a rise in passive (paracellular) HCO3- flow.
    [Abstract] [Full Text] [Related] [New Search]