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  • Title: [Effect of nisoldipine on cultured myocardial cells of neonatal rats].
    Author: Yang JC, Yu CL, Zhang JX, Gu WX, Ding MX, Yao YF.
    Journal: Zhongguo Yao Li Xue Bao; 1989 Mar; 10(2):118-21. PubMed ID: 2510457.
    Abstract:
    Nisoldipine 1.5 nmol/L, 0.75, and 1.5 mumol/L depressed the beat rates of myocardial cells. The effects were negatively correlated with dosages. Nisoldipine depressed the beat rates increased by calcium chloride 0.15 mmol/L or isoprenaline 1.5 mumol/L and atropine 20 nmol/L. Conversely, the above drugs reversed the beat rates depressed by nisoldipine. Therefore, the acting nisoldipine may be antagonistic to calcium chloride, isoprenaline and atropine. In addition, nisoldipine 10 nmol/L may significantly aggravated the damage to myocardial cells induced by mitomycin C 5 micrograms/ml in which elevated lactate dehydrogenase appeared.
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