These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


PUBMED FOR HANDHELDS

Search MEDLINE/PubMed


  • Title: Deprenyl suppresses the oxidant stress associated with increased dopamine turnover.
    Author: Cohen G, Spina MB.
    Journal: Ann Neurol; 1989 Nov; 26(5):689-90. PubMed ID: 2510589.
    Abstract:
    Tissue glutathione disulfide (GSSG) was studied as an index of changes in redox state in the striatum. When increased turnover of dopamine was provoked in mice by injection of haloperidol (1 mg/kg), the concentration of GSSG in the striatum tripled. Deprenyl (2.5 mg/kg) suppressed the rise in GSSG by 71.9%. These results indicate that deprenyl suppresses an oxidant stress associated with increased dopamine turnover.
    [Abstract] [Full Text] [Related] [New Search]