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  • Title: Pharmacological stimulation of chromaffin cell proliferation in the adult adrenal medulla.
    Author: Tischler AS, Ruzicka LA, Donahue SR, DeLellis RA.
    Journal: Arch Histol Cytol; 1989; 52 Suppl():209-16. PubMed ID: 2510782.
    Abstract:
    Many strains of rats develop adrenal medullary hyperplasia and/or neoplasia after chronic administration of a wide variety of pharmacologic agents. The same changes may occur spontaneously in the course of aging. Current evidence suggests that chromaffin cell proliferation in adult rats is regulated by a combination of hormonal and neurogenic signals. Drugs associated with adrenal medullary tumors might act directly or indirectly on the hypothalamic-endocrine axis or the autonomic nervous system to stimulate chromaffin cell proliferation through mechanisms which normally adjust cell number to meet physiological needs. The increased cell turnover rate might be a prelude to other events leading to neoplastic transformation.
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