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  • Title: Effects of interleukin-18 on bioelectric activity of rat atrial cardiomyocytes under normal conditions and during gradual stretching of the tissue.
    Author: Mitrokhin VM, Makarenko EY, Abramochkin DV, Sutyagin PV, Kamkin AG.
    Journal: Bull Exp Biol Med; 2014 Aug; 157(4):409-12. PubMed ID: 25110072.
    Abstract:
    Effects of IL-18 (50 ng/ml) on bioelectric activity of rat atrial cardiomyocytes under normal conditions and after gradual stretching of the tissue was studied using microelectrode technique. It was shown that in 85% experiments, IL-18 increased the duration of action potential at the level of 25, 50, and 90% repolarization without changing the magnitude of the resting potential, amplitude and repetition rate of action potentials, and cardiomyocyte contraction force. In addition, IL-18 abolished mechanically induced changes in the shape of action potentials during stretching.
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